Open Philanthropy is a grantmaking organization dedicated to maximizing the positive impact of its resources by funding initiatives that address critical global issues. With a mission centered on helping others, Open Philanthropy emphasizes openness to various possibilities and selects its focus areas based on their importance, neglectedness, and tractability. The organization currently operates in several program areas, including Global Aid Policy, Global Health R&D, Global Public Health Policy, Farm Animal Welfare, Biosecurity and Pandemic Preparedness, and Potential Risks from Advanced Artificial Intelligence. Open Philanthropy is launching a new program aimed at promoting economic growth in low- and middle-income countries (LMICs), with a significant budget commitment, and seeks to develop strategic grantmaking initiatives that can lead to substantial benefits in these regions.